Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

20 May 2010

Usefulness of perfusion-weighted MR imaging in the differential diagnosis of Alzheimer’s disease and mild cognitive impairment

Anna Zimny, Paweł Szewczyk, Anna Czarnecka, Elżbieta Trypka, Renata Wojtyńska, Jerzy Leszek, Marek Sąsiadek

Med Sci Monit 2010; 16(1): 5-10 :: ID: 880575

Abstract

Background: Accurate diagnosis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI) is still a clinical problem. The aim of the study was to evaluate the usefulness of perfusion-weighted magnetic resonance (MR) imaging (PWI) and analysis of disturbances in the cerebral microcirculation in the differential diagnosis of AD and MCI.
Material/Methods: Thirty-four patients with AD (mean age, 71.6 years; Mini-Mental State Examination [MMSE] 18), 23 with MCI (mean age, 66.2 years; MMSE, 27), and 15 normal control subjects (mean age, 69 years; MMSE, 29.5) were enrolled in the study. All subjects underwent psychiatric examination and psychological tests. PWI was performed on a 1.5-T MR unit using dynamic susceptibility contrast (DSC) method (IV contrast, 0.3 mM/kg, 5 mL/s). Cerebral blood volume (CBV) measurements relative to cerebellum (rCBV) were assessed in both hippocampi, and temporoparietal and frontal association cortices as well as in the posterior cingulate region.
Results: Significantly lower rCBV values (P<.05) were found in temporoparietal, left frontal, and posterior cingulate cortices in AD patients compared with normal control subjects and in temporoparietal cortices and posterior cingulate region compared with MCI patients. In MCI patients, significantly lower rCBV values were noticed in the left frontal and posterior cingulate cortices compared with normal control subjects.
Conclusions: Our results confirm an important role of cerebral hypoperfusion, particularly in the posterior cingulate region, in the pathogenesis of AD and MCI. Assessment of rCBV, especially in the posterior cingulate cortex, can be useful in the differential diagnosis of AD and MCI.

Keywords: cerebral perfusion, magnetic resonance, Alzheimer’s Disease, Dementia

Add Comment 0 Comments

Editorial

01 February 2025 : Editorial  

Editorial: Current Approaches to Screening for Lung Cancer in Smokers and Non-Smokers

Dinah V. Parums

DOI: 10.12659/MSM.948255

Med Sci Monit 2025; 31:e948255

0:00

In Press

Clinical Research  

Immune Dysregulation in Acute Herpes Zoster: Predictive Factors for Postherpetic Neuralgia

Med Sci Monit In Press; DOI: 10.12659/MSM.944688  

0:00

Clinical Research  

Inflammatory Biomarkers from Blood Counts as Prognostic Tools in Metastatic Esophageal Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.947202  

Laboratory Research  

Comparison of Color Stability Between Single-Shade and Conventional Composite Resins Following Immersion in...

Med Sci Monit In Press; DOI: 10.12659/MSM.946784  

Clinical Research  

Evaluation of Knowledge, Attitudes, and Practices Toward Thyroid Nodules in 456 Patients with Thyroid Nodules

Med Sci Monit In Press; DOI: 10.12659/MSM.945732  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,966,841

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   701,694

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   25,087

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   19,746

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750